- 1 - HAb 18 G / CD 147 Promotes pSTAT 3 - Mediated Pancreatic Cancer Development via CD 44 s

نویسندگان

  • Ling Li
  • Wenhua Tang
  • Xiaoqing Wu
  • David Karnak
  • Xiaojie Meng
  • Rachel Thompson
  • Xinbao Hao
  • Yongmin Li
  • Xiaotan T. Qiao
  • Jiayuh Lin
  • James Fuchs
  • Diane M. Simeone
  • Zhi-Nan Chen
  • Theodore S. Lawrence
  • Liang Xu
چکیده

Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, MI; USA Cell Engineering Research Centre and Department of Cell Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi’an, China Departments of Molecular Biosciences and Radiation Oncology, University of Kansas, Lawrence, KS, USA Department of Hematology/Oncology, Hainan University Medical School, Haikou, Hainan, China Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA Department of Pediatrics, College of Medicine, Ohio State University, Columbus, OH, USA Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Ohio State University, Columbus, Ohio, USA Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI, USA

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Ara-C increases gastric cancer cell invasion by upregulating CD-147-MMP-2/MMP‑9 via the ERK signaling pathway.

Gastric cancer cell are not particularly sensitive to Ara-C, a deoxycytidine analog that affects DNA synthesis. In the present study, AGS and MKN-45 gastric cancer cell lines were treated with Ara-C to determine its role in cell prolife-ration and apoptosis. The antiproliferative effect of Ara-C was assessed using the Cell Counting kit-8. Gelatinase zymography was utilized to detect the activit...

متن کامل

Cadmium Exposure as a Putative Risk Factor for the Development of Pancreatic Cancer: Three Different Lines of Evidence

Although profoundly studied, etiology of pancreatic cancer (PC) is still rather scant. Exposure to cadmium (Cd), a ubiquitous metal associated with well-established toxic and carcinogenic properties, has been hypothesized to one putative cause of PC. Hence, we analyzed recently published observational studies, meta-analyses, and experimental animal and in vitro studies with the aim of summarizi...

متن کامل

Akt/PKB-mediated phosphorylation of Twist1 promotes tumor metastasis via mediating cross-talk between PI3K/Akt and TGF-β signaling axes.

UNLABELLED Metastatic breast tumor cells display an epithelial-mesenchymal transition (EMT) that increases cell motility, invasion, and dissemination. Although the transcription factor Twist1 has been shown to contribute to EMT and cancer metastasis, the signaling pathways regulating Twist1 activity are poorly understood. Here, we show that Twist1 is ubiquitously phosphorylated in 90% of 1,532 ...

متن کامل

Effect of Salinity and Cadmium on Chlorophyll Content, Antioxidant Activity and Weight of Kochia Plant (Kochia indica)

In order to investigate the effect of salinity and cadmium (Cd) on yield, chlorophyll content and antioxidant activity of Kochia plant, a factorial experiment in a completely randomized design with three replications was conducted under greenhouse conditions. The experimental treatments included five Cd levels (0, 5, 30, 60 and 90 mg Cd kg-1 soil as cadmium sulphate) and three salinity levels (...

متن کامل

PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network.

Initiation of pancreatic ductal adenocarcinoma (PDAC) is driven by oncogenic KRAS mutation, and disease progression is associated with frequent loss of tumor suppressors. In this study, human PDAC genome analyses revealed frequent deletion of the PTEN gene as well as loss of expression in primary tumor specimens. A potential role for PTEN as a haploinsufficient tumor suppressor is further suppo...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2013